闫海静
编辑:js77999金莎官网编辑  来源:js77999金莎官网原创  浏览次数: 发布日期:2013-08-31 16:31:33 【

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2008-2013       浙江大学药理学,博士学位

2013-     滨州医学院代谢与神经精神疾病研究所


研究方向:博士期间研究中枢神经损伤修复与功能重建以及中枢组胺及其受体对脑损伤的神经保护作用及机制研究。目前研究课题为脂肪因子的神经保护作用分子机制。

代表论著:

1.Li XM, Yan HJ, Guo YS, Wang D.The role of leptin in central nervous system diseases.Neuroreport. 2016 Mar 23;27(5):350-5. 

2.Zhang X, Yuan Y, Jiang L, Zhang J, Gao J, Shen Z, Zheng Y, Deng T, Yan H, Li W, Hou WW, Lu J, Shen Y, Dai H, Hu WW, Zhang Z, Chen Z.

 Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Autophagy. 2014 Oct 1;10(10):1801-13. 

3.Yan H, Zhang X, Hu W, Ma J, Hou W, Zhang X, Wang X, Gao J, Shen Y, Lv J, Ohtsu H, Han F, Wang G, Chen Z. Histamine H3 Receptors Aggravate Cerebral Ischemic Injury by histamine-independent mechanisms. Nat Commun. 2014 Feb 25;5:3334. doi: 10.1038/ncomms4334. 

4.Zhang X, Yan H (共同第一编辑), Yuan Y, Gao J, Shen Z, Cheng Y, Shen Y, Wang RR, Wang X, Hu WW, Wang G, Chen Z. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy 2013, 9(9):1321-33. 

5. Hu Weiwei, Fang Qi, Zhenghao, Yan Haijing, He Ping, Zhong Kai, anying, Yang Ying, iangnan, hunyang, Ohtsu H, Xu Tianle, Chen Zhong. (2012). Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase. CNS Neurosci Ther 2013, 18: 683-690.  

6. Ma Jing, Xiong Jiayan, Hou Weiwei, Yan Haijing, Sun Yun, Hu Weiwei, Chen Zhong. Protective effect of carnosine on subcortical ischemic vascular dementia in mice. CNS Neurosci Ther 2013, 18: 745-753.  

7. Fang Qi., Hu Weiwei, Wang Xiaofen, Yang Ying, Lou Guodong, Jin Miaomiao, Yan Haijing, Zeng, W.Z., Shen, Y., Zhang, S.H., Chen Zhong. Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against  

8.Wang Xiaofen , Hu Weiwei, Yan Haijing, Tan Li, Gao Jieqiong, Tian, Y.Y., Shi, X.J., Hou, W.W., Li, J., Shen, Y., Chen Zhong.  Modulation of astrocytic glutamine synthetase expression and cell viability by histamine in cultured cortical astrocytes exposed to OGD insults. Neurosci Lett 2013, 549:69-73. IF=2.026  

9.Shen Yao, He Ping, Fan Yanying, Zhang Jianxiang, Yan Haijing, Hu Weiwei, Ohtsu H, chen zhong. Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity. Free Radic Biol Med 2010, 48: 727-735.  


承担课题:

1.国家自然科学基金项目:脂联素对阿尔茨海默症的神经保护作用及其机制研究。立项时间:2016-2018年,负责人:闫海静。

2.山东省自然科学基金青年基金项目:脂联素的神经保护作用及其分子机制研究(2014ZRB14362)。立项时间:2014-2016,负责人:闫海静。


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